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Health and Longevity news (from KurzweilAI.net)

Disease Cause Is Pinpointed With Genome
New York Times, Mar. 10, 2010

Two research teams have independently decoded the entire genome of patients to find the exact genetic cause of their diseases. The approach may offer a new start in identifying the genetic roots of major killers like heart disease, diabetes and Alzheimer's.

Geneticists said the new research showed it was now possible to sequence the entire genome of a patient at reasonable cost and with sufficient accuracy to be of practical use to medical researchers. One subject's genome cost just $50,000 to decode.
Designer nano luggage to carry drugs to diseased cells
Physorg.com, Mar. 9, 2010

Particles derived from the Cowpea mosaic virus that can carry anti-cancer agents to cancer cells have been developed by researchers at Norwich BioScience Institutes.
Exclusive: Colorado Doctors Skirt FDA Jurisdiction to Provide Stem Cell Therapies
Singularity Hub, Mar. 9, 2010

Regenerative Sciences in Broomfield, Colorado provides its patients with the Regenexx procedure, an adult stem cell transplant that uses your own cells (autologous) to treat joint injuries and bone damage.

Human stem cell therapies like this one aren't approved by the FDA.
Speed Reading of DNA May Help Cancer Treatment
New York Times, Mar. 8, 2010

Researchers at Johns Hopkins University have developed a way to monitor the progress of a patient's cancer treatment using a new technique for rapidly sequencing, or decoding, large amounts of DNA.

It uses mitochondrial DNA as markers of cancerous cells, based on the finding that more than 80 percent of cancers had mutations in their mitochondrial DNA.


MIT builds first sensor to to detect single molecules produced by living cells
KurzweilAI.net, March/April 2010

MIT researchers have built the first sensor array that can detect single molecules produced by living cells, using a carbon nanotube sensor array that can detect hydrogen peroxide molecules and could help scientists learn more about that molecule's role in cancer.

The sensor consists of a film of carbon nanotubes embedded in collagen. Cells can grow on the collagen surface, and the collagen also attracts and traps hydrogen peroxide released by the cell. When the nanotubes come in contact with the trapped hydrogen peroxide, their fluorescence flickers. By counting the flickers, one can obtain an accurate count of the incident single molecules.

More info: MIT news
Using own skin cells to repair hearts on horizon
Physorg.com, Mar. 2, 2010

A heart patient's own skin cells soon could be used to repair damaged cardiac tissue thanks to pioneering stem cell research by University of Houston biomedical scientist Robert Schwartz.
Personalized Medicine on the Spot
Technology Review, March/April 2010

Nanosphere's Verigene system, which takes just a few hours to analyze DNA from blood or other material, allows doctors to test for genetic variations without having to send samples out to a lab.





Rising Threat of Infections Unfazed by Antibiotics
New York Times, Feb. 26, 2010

Gram-negative bacteria are killing tens of thousands of hospital patients each year, spreading worldwide, and evolving to become ever more immune to existing antibiotics, with some strains resistant to virtually every antibiotic.


Long-promised cancer revolution begins
New Scientist/Short Sharp Science, Feb. 19, 2010

A personalized blood test that can be used to spot cancer recurrence before tumor growth shows up on scans has been developed by researchers at Johns Hopkins Kimmel Cancer Center and Science Translational Medicine.

The test detects genetic rearrangements that distinguish cancer cells from normal cells. Eventually it might also pave the way for more personalized cancer treatments tailored to the genetic signature of individuals' tumors.
Random fluctuations give rise to odd genetic phenomenon
Physorg.com, Feb. 17, 2010

MIT biophysicists have demonstrated that some cases of incomplete penetrance* are controlled by random fluctuations in gene expression, which could influence the mutations that can cause cancer.

Knowing the specific points in cellular pathways that are most important in controlling a cell's response to mutation could give drug designers better targets for new therapies.

* Not every person who carries a mutated gene expresses the trait or condition associated with the mutation. Some of this variation may be due to environmental factors and the influence of other genes, but not all: It has been shown that genetically identical organisms living in the same environment can show variability in some incompletely penetrant traits.
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Health and Longevity articles (from KurzweilAI.net)

Bootstrapping our way to an ageless future
By Aubrey de Grey
(Added September 19th 2007)

Biomedical gerontologist Aubrey de Grey expects many people alive today to live to 1000 years of age and to avoid age-related health problems even at that age. In this excerpt from his just-published, much-awaited book, Ending Aging, he explains how.

Press ignores bias in study of multivitamins and prostate cancer
By Ray Kurzweil and Terry Grossman
(Added May 25th 2007)

In a recent paper reporting on the National Cancer Institute study of multivitamin use and the risk of prostate cancer, the NCI authors cited several possible bias factors. An analysis by Ray Kurzweil and Terry Grossman shows why the study’s biases should be considered before drawing conclusions.

Strategic Sustainable Brain
By Natasha Vita-More
(Added March 31st 2006)

The human brain faces a challenging future. To cope with accelerating nanotech- and biotech-based developments in an increasingly complex world, compete with emerging superintelligence, and maintain its performance and sustainability as people live longer, the fragile human brain will need major enhancements: a backup system, eliminating degenerative processes, direct mind-linkup to ubiquitous computing networks, error-correction for memory, and a global Net connection with remote neural access.

Nanoethics and Human Enhancement
By Patrick Lin and Fritz Allhoff
(Added March 31st 2006)

Radical nanotech-based human enhancements such as bionic implants and "respirocyte" artificial red blood cells will become technologically viable in the near future, raising profound ethical issues and forcing us to rethink what it means to be human. Recent pro-enhancement arguments will need to be critically examined and strengthened if they are to be convincing.

Reprogramming your Biochemistry for Immortality
By Ray Kurzweil
(Added March 8th 2006)

Scientists are now talking about people staying young and not aging. Ray Kurzweil is taking it a step further: "In addition to radical life extension, we’ll also have radical life expansion. The nanobots will be able to go inside the brain and extend our mental functioning by interacting with our biological neurons."

Nanotechnology, Nanomedicine and Nanosurgery
By Robert A. Freitas Jr.
(Added February 13th 2006)

The ability to build complex diamondoid medical nanorobots to molecular precision, and then to build them cheaply enough in sufficiently large numbers to be useful therapeutically, will revolutionize the practice of medicine and surgery.

Ray Kurzweil's Plan for Cheating Death
By Terry Grossman
(Added February 3rd 2006)

A cure for aging may be found in the next fifty years. The trick now is to live long enough to be there when it happens. In his two new books, Ray Kurzweil has painted a clear picture of the future and provided a blueprint for how to get there.

Interview with Robert A. Freitas Jr. Part 2
By Robert A. Freitas Jr. and Sander Olson
(Added February 2nd 2006)

There are very few diseases or conditions--including infectious diseases--aside from physical brain damage, that cannot be cured using nanomedicine, says nanomedicine pioneer Robert A. Freitas Jr. He believes nanomedicine's greatest power will emerge in a decade or two as we learn to design and construct complete artificial nanorobots using diamondoid nanometer-scale parts and subsystems.

Ray Kurzweil's Dangerous Idea
By Ray Kurzweil
(Added January 17th 2006)

"What is your dangerous idea?" Over one hundred big thinkers answered this question, as part of The Edge's Annual Question for 2006. Ray Kurzweil's dangerous idea? We can achieve immortality in our lifetime.

Open-Source Biology And Its Impact on Industry
By Rob Carlson
(Added March 3rd 2004)

Technology based on intentional, open-source biology is on its way, whether we like it or not. Distributed biological manufacturing is the future of the global economy and will occur as inexpensive, quality DNA sequencing and synthesis equipment becomes available to anyone. In 2050, garage biology hacking will be well under way. Fear of potential hazards should be met with increased research and education, rather than closing the door on the profound positive impacts that distributed biological technology will have on human health, human impacts on the environment, and increasing standards of living around the world.

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